Increased water consumption and urination.If left untreated, however, hypoadrenocorticism can be life-threatening. Signs of the disease can wax and wane for a long time. Prospective pet parents of these breeds should inquire about the history of hypoadrenocorticism in their dog's family. Genetic analysis has revealed the heritability of the disease in some of these at-risk breeds. While it can affect any sex or breed, certain breeds have a higher predisposition. Unlike many diseases manifest in older dogs, hypoadrenocorticism primarily affects young to middle-aged dogs, though older dogs are occasionally diagnosed with the ailment. Hypoadrenocorticism is a disease of low hormone output from the adrenal glands and can take different forms based on the hormones involved. It is a chameleon of a disease, mimicking the signs of other more common canine health problems, which makes it a diagnostic challenge for veterinarians. Updated Janu– Hypoadrenocorticism is an uncommon yet severe and sometimes life-threatening disease in dogs.